Model NO.: 80mg: 2ml (4%)
Product Name: Gentamicin Sulfate Injection
Ingredient: Gentamicin Sulfate
Characteristic: a Clarity and Colorless Solution
Standards: Bp 2000
Package Design: as Your Demand
Shipment: Usually 40 Days After The Deposit Is Received
Trademark: Print your brand
Origin: Qingdao, Shandong
HS Code: 3004909099
Gentamicin is a kind of aminoglycoside. Its mechanism is to act on the ribosome of bacteria, inhibit bacterial protein synthesis, and destroy the integrity of bacterial cell membrane. Gentamicin can first pass through the cell membrane pore protein through the passive diffusion, and then enter the cell through the cell membrane through the transport system, and not reversibly bind to the separated ribosome 30S subunit, which leads to the destruction of the A site.
1.prevent the correct positioning of the ammonia tRNA at the A position, especially the binding of thiamyl tRNA, which interferes with the assembly of functional ribosomes and inhibits the formation of the 70S initiating complex.
2.a mismatch between tRNA and mRNA codon three, which causes the 30S subunit of the complete ribosome to misread the genetic code, causing the wrong amino acid to insert the protein structure and lead to the abnormal, non functional protein synthesis.
3.hindering the termination factor from binding to the A site, the synthesized peptide chain can not be released and prevents the complete ribosomal dissociation of 70S.
4.hindering the process of depolymerization and assembly of ribosomes, causing ribosome depletion in bacteria. Gentamicin has strong antibacterial activity against Pseudomonas aeruginosa, proteus (indole positive and negative), Escherichia coli, Klebsiella, Enterobacteriaceae, Sarre, Shigella, citrate, Neisseria, and Staphylococcus aureus (excluding methicillin resistant strains). Gentamicin was ineffective for Streptococcus (including Streptococcus pyogenes, pneumococcus, Streptococcus faecalis, etc.), anaerobes (bacteriobacterium), Mycobacterium tuberculosis, Rickettsia, virus and fungi.