Product name: neomycin sulfate soluble powder
Appearance: hite or yellowish powder
Application: Used in poultry e. coli and salmonella and other gram-negative bacteria caused by escherichia coli, such as pullorosis
Storage: Seal and keep in dry place
Pharmacological activities, pharmacodynamics, neomycin belongs to aminoglycoside antibiotic, antibacterial spectrum similar to kanamycin, for the majority of gram-negative bacilli, such as e. coli, proteus, salmonella and kill pasteurella has strong antimicrobial effect, and so on is more sensitive on staphylococcus aureus, pseudomonas aeruginosa, gram-positive bacteria (staphylococcus aureus, except), rickettsia, anaerobic bacteria and fungi, etc. This article in drug resistance.
Pharmacokinetics, neomycin intravenous administration and local application are rarely absorbed, only 3% of the total amount is excreted from urine after intravenous administration, and most of the amount is not changed from feces. When intestinal mucosa is inflamed or has ulcer, absorption can be increased.
Drug interactions, (1) with large ring lactone class antibiotics, treatment of mastitis caused by gram positive bacteria, (2) can affect the digitalis drugs take orally, the absorption of vitamin A and vitamin B12, (3) with penicillin and cephalosporin class share synergy, 4. This product in alkaline environment, enhanced antibacterial and alkaline drugs (such as sodium bicarbonate, ammonia alkali tea, etc.) share can strengthen antibacterial efficacy, toxicity but also enhanced accordingly, when PH value is greater than 8.4, the antibacterial effect is abate, instead 5. Calcium, magnesium, sodium, ammonium ion, Cations such as potassium can inhibit the antibacterial activity of this product. 6. Combined with cephalosporin, dextran, potent diuretic and erythromycin, can enhance the ototoxicity of this product.