Product name: erythromycin thiocyanate soluble powder
Molecular weight: 793.02
Appearance: White or white powder
Application: An infectious disease caused by gram-positive bacteria and mycoplasma in chickens
Storage: Shade, close, keep in the shade
Pharmacological activities, pharmacodynamics, erythromycin is a large ring lactone class antibiotic, the product effect on gram-positive bacteria similar to penicillin, wide, but its antibacterial spectrum is penicillin are sensitive gram positive bacterium staphylococcus aureus, including penicillin resistant staphylococcus aureus, pneumococcus, ryukyu all, bacillus anthracis, swine erysipelas coli, listeria monocytogenes, clostridium corruption, such as clostridium emphysematous gangrene, sensitive to gram-negative bacterium h. influenzae, meningitis diplococcus, brucella, pasteurella, etc., in addition, campylobacter, mycoplasma, chlamydia, rickettsia and leptospira also has good effect, The antibacterial activity of erythromycin thiocyanate in alkaline solution, when PH increased from 5.5 to 5.5, the antibacterial activity increased, the bacteria can easily by chromosome mutation of erythromycin thiocyanate to produce high levels of drug resistance, and type of this kind of drug-resistant form that can appear in the process of treatment, the drug resistance plasmid mediated by bacteria erythromycin thiocyanate is relatively common, mainly through methylation drugs targeted, erythromycin thiocyanate and other large ring lactone class and clindamycin cross resistance are more common,
Pharmacokinetic, erythromycin and stearic acid alkali salt internal and are easily by acid degradation, erythromycin salt types, dosage form, the acidity of the gastrointestinal tract and stomach in food are affecting the bioavailability, only enteric preparation can better absorption, absorption after widely distributed throughout the tissues and fluids, but rarely into the cerebrospinal fluid, plasma proteins combined rate of 73% ~ 73%, erythromycin small hepatic metabolism of inactive N - methyl erythromycin, mainly by the prototype from bile excretion, only 2% ~ 5% dose to prototype from the urine.