● ProName: Cisplatin Manufacturer.
● CAS No: 15663-27-1
● Molecular Formula: Cl2H6N2Pt
● Appearance: Yellow crystal
● Application: It is an important raw material and in...
● Delivery Time: prompt
● Package: according to the clients requirement
● Port: Shanghai
● Production Capacity: 1-100 Metric Ton/Month
● Purity: 99%
● Storage: Store in dry, dark and ventilated place
● Transportation: by sea or by air
● Limit Num: 1 Kilogram
● Grade: Industrial Grade
Cisplatin is also called cisplatin, chloramplatin, DDP, tin platinum, ethylene platinum, CIS dichlorodichloroplatin, which are commonly used as platinum complexes. The platinum atoms are of great significance in the anti-tumor effect of the molecules. But only the CIS is meaningful, and the opposite is ineffective. It can be cross linked with DNA chain, showing cytotoxic effect. After dissolution, there is no need for carrier transport in vivo. Due to low intracellular chloride concentration (4mmol/L), chlorine ion is replaced by water, and the charge is positive. It has a function similar to alkylating double functional groups. It can combine with the base of DNA in the nucleus to form three forms of crosslinking, causing DNA damage, destroying DNA replication and transcription, and inhibiting the synthesis of RNA and protein at high concentration.
Cisplatin is widely used in the treatment of testicular cancer, ovarian cancer, uterine cancer, bladder cancer, neck cancer, prostate cancer, brain cancer and so on. It has a significant effect on the treatment of testicular cancer, ovarian cancer, uterine cancer, bladder cancer, cervical cancer, prostate cancer, and brain cancer. However, cisplatin has certain toxicity and may cause side effects in the treatment of cancer. Therefore, it is necessary to constantly seek analogues with less toxicity and clinical effect similar to cisplatin.
So far, scientists have synthesized and examined thousands of metal complexes related to cisplatin, and developed the second generation platinum complexes represented by carbon platinum. The third generation of anticancer metal complexes have also been found to be represented by two chloro titanium. These compounds are independent of cisplatin from a chemical point of view, but they have a good effect on certain carcinogenesis with little effect on cisplatin and do not harm renal function. Much research is continuing in this field, focusing on exploring the mechanism of anticancer activity of metal complexes at the molecular level. China has produced cisplatin products and carried out research in this field.