Cinnamic Aldehyde Metabolism And Transport

- Jun 12, 2018-

Cinnamic aldehyde that enters the body is quickly converted to cinnamic acid

The conversion of Cinnamic aldehyde to cinnamic acid occurs first in the gastrointestinal contents and in the gastrointestinal mucosa. Without the support of techniques such as coating, a large portion of Cinnamic aldehyde penetrates the stomach membrane and enters the portal vein. Studies on SD rats have found that trace amounts of cinnamic acid can be detected in the stomach contents after oral administration of Cinnamic aldehyde, and the content of cinnamic acid in the intestinal contents is close to that of Cinnamic aldehyde; this test also shows that over time After prolonged, the total concentration of Cinnamic aldehyde and cinnamic acid consumed after 30 minutes decreased by about 30%. Overall, the former indicated that during the emptying of the gastrointestinal contents, a large amount of Cinnamic aldehyde was converted into cinnamon in the gastrointestinal contents. Acid; the latter indicates that Cinnamic aldehyde absorbs into the blood through the stomach membrane. Cinnamic aldehyde can be rapidly converted into cinnamic acid in small intestinal cells. Studies using rat intestinal fluid found that the addition of Cinnamic aldehyde to the intestinal mucosal fluid, serosal fluid, and intestinal homogenate resulted in a rapid increase in the production and rate of cinnamic acid.

Cinnamic aldehyde can be rapidly converted into cinnamic acid after ingestion into the body, and the conversion process mainly occurs before entering the inferior vena cava. The test of Cinnamic aldehyde feeding showed that the content of Cinnamic aldehyde in the blood was much lower than that of cinnamic acid, indicating that almost all of the Cinnamic aldehyde was converted to cinnamic acid during transit through the gastrointestinal mucosa, hepatic portal vein and liver to the inferior vena cava. The test also found similar results. The test that mice were fed with cinnamon oil and cinnamic acid, respectively, found that Cinnamic aldehyde caused a high concentration of cinnamic acid in the blood for a long period of time. After the intake of cinnamic acid, the cinnamic acid in the blood would Quickly disappear.