TiotropiuM BroMide Monohydrate

TiotropiuM BroMide Monohydrate

Product name :TiotropiuM BroMide Monohydrate CAS No: 139404-48-1 Molecular Formula: C19H22BrNO4S2.H2O Appearance: white powder Application: Anticholinergic drugs Package: according to the clients requirement Port: Shanghai Production Capacity: 50kg/month Purity: 99% Storage: Keep in cool, dry and sealed Transportation: by sea or by air MOQ:1kg
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Product Details

Product name :TiotropiuM BroMide Monohydrate

CAS No: 139404-48-1

Molecular Formula: C19H22BrNO4S2.H2O

Appearance: white powder

Application: Anticholinergic drugs

Package: according to the clients requirement

Port: Shanghai

Production Capacity: 50kg/month

Purity: 99%

Storage: Keep in cool, dry and sealed

Transportation: by sea or by air

MOQ:1kg

 

 

Product Description

 

Tiotropium bromide is a long - acting and specific anti - muscarinic drug. Tiotropium bromide inhibits the cholinergic effect (bronchoconstriction) caused by acetylcholine released by parasympathetic nerve endings by binding to the muscarinic receptor on bronchial smooth muscle. Tiotropium bromide has a similar affinity for the muscarinic receptor subtype M1~M5. In the respiratory tract, tiotropium bromide antagonizes M3 receptor competitively and reversibly, leading to smooth muscle relaxation. Bronchiectasis was dose-dependent and lasted for more than 24 hours. The long action time may be due to its very slow dissociation from M3 receptor, and its dissociation half-life is significantly longer than that of iprtropium bromide. As a tetravalent ammonium anticholinergic drug, tiotropium bromide has local (bronchial) selectivity when administered by inhalation, thus achieving therapeutic effect without generating systemic anticholinergic effect. Bronchiectasis is primarily a local effect (airway) rather than a systemic one. Tiotroponium bromide dissociated faster from the M2 receptor than from the M3 receptor, and its selectivity to the M3 receptor subtype was higher than that of the M2 receptor in vitro functional studies (kinetic control). The clinical relevance of high binding to the receptor and slow dissociation is demonstrated by the significant and long-lasting bronchodilatation effect of tiotropium bromide in patients with COPD.

 

 


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